When the red blood cell count reaches a critical number, the flowability of the blood decreases leading to restricted blood circulation. This causes a blue coloration of the skin cyanosis. The most common complications are a result of the high viscosity resistance to flow of the blood, which can lead to blood clots thrombosis.
Clogging of both small and large blood vessels embolism can also occur. Both the number of platelets and their function are responsible for the balance of the coagulation system. Hypercoagulation results in blood clotting, while lack of coagulation results in bleeding e.
The patient will be referred to a specialist hematologist for further examination if Polycythaemia Vera is suspected due to unspecified symptoms and a change in the blood count such as an increase in hemoglobin or hematocrit. During the diagnosis it is important to first check if the increase in erythrocytes does not stem from a reactive condition caused by an underlying disease. Hence, underlying conditions in the heart, lungs, liver or kidney need to be ruled out as possible causes.
The number of erythrocytes, together with the hemoglobin and hematocrit results, are elevated hemoglobin: blood pigment, hematocrit: cellular components of blood. If the kidneys suffer from a lack of oxygen, they release erythropoietin which stimulates the production of blood cells in the bone marrow erythropoiesis.
However, in the case of Polycythaemia Vera, a rise in the erythrocyte count provides the organ with a higher amount of oxygen, which leads to a decline in the production of erythropoietin. The upper abdomen should undergo an ultrasound scan in order to check the size of the liver and spleen.
These organs are sometimes swollen in patients with Polycythaemia Vera. The removal and histological examination of bone marrow from the iliac crest region may provide verification in uncertain cases. Cause The cause of Polycythaemia Vera is still unknown. Symptoms Nonspecific onset At the onset of the disorder, the signs and symptoms tend to be unspecific. Hi, I recently had a limb lead test for my arms and legs. Leads 2 and 3 were both healthy and normal but lead 1 had a regularity.
It was a slow weak signal. Naturally I'm going to be talking with my Disclaimer: This article is for information only and should not be used for the diagnosis or treatment of medical conditions.
Egton Medical Information Systems Limited has used all reasonable care in compiling the information but make no warranty as to its accuracy. Consult a doctor or other health care professional for diagnosis and treatment of medical conditions. For details see our conditions. This article is for Medical Professionals.
In this article Differential diagnosis Presentation Investigations Management. Central cyanosis Central cyanosis is caused by diseases of the heart or lungs, or abnormal haemoglobin methaemoglobinaemia or sulfhaemoglobinaemia.
Cyanosis is seen in the tongue and lips and is due to desaturation of central arterial blood resulting from cardiac and respiratory disorders associated with shunting of deoxygenated venous blood into the systemic circulation. Patients who are centrally cyanosed will usually also be peripherally cyanosed. Associated features of central cyanosis depend on the underlying cause and include dyspnoea and tachypnoea, secondary polycythaemia and bluish or purple discolouration of the oral mucous membranes, fingers and toes.
The hands and feet are usually normal temperature or warm but not cold unless there is an associated poor peripheral circulation. Are you protected against flu? Further reading and references. Join the discussion on the forums.
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